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5-Amino-1MQ Vials (50 mg each): 1 week (5 mg/day) 1 vial 2 weeks (5 mg/day) 1 vial 4 weeks (5 mg/day) 2 vials Insulin Syringes (U-100): Per week (once daily): 7 syringes Per week (BID): 14 syringes 4 weeks (once daily): 28 syringes Bacteriostatic Water (10 mL bottles): Use 4.0 mL per vial for reconstitution

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For each analysis, the statistical test used and n for each group are found in Supplemental Tables 2, 3, or 5